Urgent (without bleeding): Reversal needed within hours Non-urgent: Reversal is elective (procedures >7 days away) Risks and benefits of repeat administration are not known.Plasma dabigatran concentrations may increase 12-24 hours following reversal due to re-distribution from extravascular space.Will likely correct aPTT but correlation of improved lab results with clinical outcomes is not established.Effect on bleeding not immediate! Median time from administration to bleeding cessation may be as long as 11 hours.Reversal Agents for Oral Thrombin Inhibitors NOTE: PCC may partially correct PT/aPTT but will not affect anti-factor Xa activity and will not increase drug clearance correlation of shortening PT/aPTT with reduction in bleeding risk is unknown
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